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Chapter-15 Tests for Paroxysmal Nocturnal Haemoglobinuria (PNH)

BOOK TITLE: Laboratory Procedures in Haematology

Author
1. Mehdi SR
ISBN
9788180616570
DOI
10.5005/jp/books/10437_15
Edition
1/e
Publishing Year
2006
Pages
4
Author Affiliations
1. JN Medical College, AMU, Aligarh, India, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
Chapter keywords

Abstract

The diagnosis of PNH depends on the demonstration of the susceptibility of red cells to lyse by the complement. In a normal serum the complement is inactivated by heating at 56°C. In PNH the cells are lysed by its own serum. The test is considered positive only in the presence of properly controlled acidified serum. HEMPAS is the only condition which has to be excluded first for writing a positive PNH test. To rule out HEMPAS “Sucrose Hemolysis Test” can be performed. This test is negative in HEMPAS.

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