Malformations of Cortical Development - Review Article
Author Pasquale Capuano, Mariangela Cialdella, Vincenzo D'Addario
ISSN 0973-614X
JournalTitle Donald School Journal of Ultrasound in Obstetrics and Gynecology
DOI 10.5005/jp-journals-10009-1538
Volume 11
Issue 4
Publishing Year 2017
Pages 308-313
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Cerebral cortical malformations are common causes of neurodevelopmental delay and epilepsy and include a wide range of antenatal neurogenesis disorders. Abnormal cell proliferation leads to microcephaly or megalencephaly, incomplete neuronal migration results in heterotopia and lissencephaly, neuronal overmigration manifests as cobblestone malformations, and anomalous postmigrational cortical organization is responsible for polymicrogyria (PMG) and schizencephaly. Although corticogenesis occurs early, these rare pathologies are associated with late onset during pregnancy, which does not allow their early prenatal recognition. This review aims to give an update of current knowledge of these insidious cerebral cortical disorders.

Keywords: Cerebral cortical malformations, Fetus, Ultrasound.

How to cite this article: Capuano P, Cialdella M, D’Addario V. Malformations of Cortical Development. Donald School J Ultrasound Obstet Gynecol 2017;11(4):308-313.

Source of support: Nil

Conflict of interest: None

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