Three-dimensional Evaluation of the Fetal Brain - Review Article
Author Ritsuko K Pooh
ISSN 0973-614X
JournalTitle Donald School Journal of Ultrasound in Obstetrics and Gynecology
DOI 10.5005/jp-journals-10009-1532
Volume 11
Issue 4
Publishing Year 2017
Pages 268-275
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Three-dimensional (3D) ultrasound is one of the most attractive modalities in the field of fetal ultrasound imaging. Combination of both transvaginal sonography and 3D ultrasound may be a great diagnostic tool for evaluation of 3D structure of fetal central nervous system (CNS). Recent advanced 3D ultrasound equipments have several useful functions, such as surface anatomy imaging; multiplanar imaging of the intracranial structure; tomographic ultrasound imaging of fetal brain in the any cutting section; bony structural imaging of the calvaria and vertebrae; thick slice imaging of the intracranial structure; simultaneous volume contrast imaging of the same section or vertical section of fetal brain structure; volume calculation of target organs, such as intracranial cavity, ventricle, choroid plexus, and intracranial lesions; and 3D sonoangiography of the brain circulation (3D power or color Doppler). Furthermore, recent advanced technologies, such as HDlive silhouette and HDlive flow are quite attractive modalities and they can be applied for neuroimaging.
Up-to-date 3D technologies described in this study allow extending the detection of congenital brain maldevelopment, and it is beyond description that noninvasive direct viewing of the embryo/fetus by all-inclusive ultrasound technology is definitely the first modality in a field of fetal neurology and helps our goal of proper perinatal care and management, even in the era of molecular genetics and advanced sequencing of fetal deoxyribonucleic acid (DNA) in the maternal blood. As a future aspect, collaboration of both molecular genetics and 3D neuroimaging will reveal responsible gene mutation of neuronal migration disorder, and this fetal neuro-sono-genetics will be able to contribute to accurate diagnoses, proper management, possible genetic therapy, and prophylaxis.

Keywords: Brain, Fetus, HDlive, Silhouette, Three-dimensional ultrasound.

How to cite this article: Pooh RK. Three-dimensional Evaluation of the Fetal Brain. Donald School J Ultrasound Obstet Gynecol 2017;11(4):268-275.

Source of support: Nil

Conflict of interest: None

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